SUPRATHERAPEUTIC PT-INR IN A PATIENT ON CRIZOTINIB FOR STAGE IV NON-SMALL CELL LUNG CANCER
نویسندگان
چکیده
منابع مشابه
Management Issues for Stage IV Non-Small Cell Lung Cancer.
BACKGROUND:The management of stage IV non-small-cell lung cancer (NSCLC) has been a controversial subject over the past several decades. Data from randomized trials and from phase II trials on new cancer agents are changing physician attitudes and treatment practices. METHODS: The literature on the management of metastatic lung cancer was reviewed and interpreted. RESULTS: There is good evidenc...
متن کاملCrizotinib for the treatment of non-small-cell lung cancer.
PURPOSE The pharmacology, pharmacokinetics, clinical efficacy, safety, adverse effects, and dosage and administration of crizotinib in the management of non-small-cell lung cancer (NSCLC) are reviewed. SUMMARY Crizotinib (Xalkori, Pfizer Inc.) is a novel tyrosine kinase inhibitor approved for the treatment of patients with locally advanced or metastatic NSCLC who exhibit assay-confirmed mutat...
متن کاملTreatment of Stage IV Non-small Cell Lung Cancer
Background: Stage IV non-small cell lung cancer (NSCLC) is a treatable, but not curable, clinical entity in patients given the diagnosis at a time when their performance status (PS) remains good. Methods: A systematic literature review was performed to update the previous edition of the American College of Chest Physicians Lung Cancer Guidelines. Results: The use of pemetrexed should be restric...
متن کاملChemotherapeutic management of stage IV non-small cell lung cancer.
Stage IV non-small cell lung cancer (NSCLC) denotes the presence of metastatic disease and is largely incurable using present-day therapies. Chemotherapy remains a therapeutic option in this patient population, and there are many pertinent issues surrounding its use in patients with stage IV NSCLC. Eleven questions were framed by the American College of Chest Physicians Lung Cancer Guidelines C...
متن کاملTherapy for stage IIIB and stage IV non-small cell lung cancer.
The treatment options for unresectable stage III NSCLC include definitive RT, chemotherapy, combined chemoradiotherapy, or supportive care. Compared with radiation alone or chemotherapy alone, the combination of chemotherapy and standard RT confers a modest survival benefit at the cost of increased toxicity for patients with an excellent performance status. For metastatic disease, combination c...
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ژورنال
عنوان ژورنال: Chest
سال: 2019
ISSN: 0012-3692
DOI: 10.1016/j.chest.2019.08.586